Artificial intelligence (AI) has graduated from science fiction to commoditized widget form, readily able to snap into many processes of daily life. Hence, enterprises of all maturity levels are increasingly eager to explore AI’s roles in their innovation, or outright survival strategies. Concurrently, ethical and responsible development and execution of AI-based solutions will increasingly become critical for purposes of safety and fairness. Ensuring that AI proliferates along the right path will require the infusion of multi-faceted research activities along the entire AI lifecycle. We will discuss the challenges and opportunities regarding this topic in this presentation.